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Trace Metal Bioanalysis and Biomarker Quantification by ICP-MS & IC

Trace metals bioanalysis services by inductively coupled plasma-mass spectrometry (ICP-MS), inductively coupled plasma–optical emission spectrometry (ICP-OES) & ion chromatography (IC) supporting pharmacokinetics studies for metal based drugs or quantification of trace metals in biomarker studies.

The use of ICP and IC to perform elemental analysis are tried and trusted techniques, and with the advent of metal compounds being used in such pharmaceutical products they are finding new life in the bioanalytical field.  These techniques provide insight in the parts per billion (ppb) and parts per trillion (ppt) detection range, very useful in areas such as pharmacokinetic studies (PK) and biomarker projects. 

Impact’s Metals Bioanalysis Expertise 

Utilizing our ICP-MS, ICP-OES and new Gradient IC  our team of experts are able to deliver accurate, quality reviewed data supporting multiple study types. We are able to perform single element or multi-element studies depending on the needs of our clients. Our lab team, under the guidance of Dr. Sayyarpour can provide services such as method development and validation, and then apply this to your project  across a wide range of clinical samples including plasma, serum, whole blood and other matrices.

Typical services would include:

Biomarker Quantification
Metals are being used more frequently to aid in the detection and diagnosis of diseases.  Their use will help with the early detection of diseases.

Metal Bioanalysis for Preclinical or Clinical Studies
Metals are being used across the spectrum in the pharmaceutical/ Medical Device world.  They are being tested in cancer drugs (for example platinum) and drugs targeted at treating Rheumatoid Arthritis (with gold compounds). Medical devices such as implants or pacemakers may also impart metal elements such as titanium or chromium or nickel that may leach from the device. Determining these metals in preclinical and clinical samples is vital, however, the analysis of these elements at very low detection limits in complex biological matrices can present challenges.

 

Metals Bioanalysis Services:

    • Rapid discovery phase bioanalysis
    • Method development
    • Method validation (GLP/GCP)
    • Method transfer
    • GLP/GCP quantitative analysis
    • Biomarker studies
    • Biomonitoring studies
    • Detection and quantification of anions and cations such as phosphate, halide, sulphate, sodium and other alkali metals, ammonium salts and amino acids by ion chromatography

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