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DMPK & ADME Services

 

Researchers gain critical insights into drug behavior, enabling data-driven decisions regarding which drug candidates are the most viable for further therapeutic exploration with our wide range of ADME and DMPK laboratory services for in vivo and in vitro samples.

Adsorption, distribution, metabolism, and excretion (ADME) and drug metabolism and pharmacokinetics (DMPK) analysis is a critical component of drug discovery and development. ADME and DMPK studies of drug candidates allow drug developers to fully evaluate the potential of a specific formulation and determine dosing requirements. Assessments of drug metabolism and pharmacokinetics are essential – they provide researchers with key insights into in vivo drug behavior. The results of these studies can help drug developers help determine which drug candidates warrant further therapeutic exploration, and which do not. Provided that DMPK analysis takes place throughout preclinical and clinical research, drug developers repeatedly require efficient DMPK/ADME testing to remain competitive and avoid costly missteps in lead candidate selection and advancement.

Our bioanalytical laboratory supports drug discovery and development programs by designing and executing DMPK analysis and ADME assays. In addition to a host of available in vitro ADME assays, customers benefit from custom method development and a steadfast commitment to high quality, thorough, and swift testing of preclinical and clinical samples. Get data back faster without sacrificing thoroughness or quality with rapid turnaround times. Ready to start the conversation? Get in touch with our DMPK lab today.

Well-established in vitro ADME assays that can be readily adapted to specific drug candidates enable our bioanalytical speed. Using these methods, dosage regimens can be evaluated, routes of administration compared, and basic safety assessments can be performed on animal model samples supplied by pharmaceutical partners. Jumpstart progress with these essential analyses, getting an early understanding of the candidate’s DMPK behavior and supporting IND-submissions.

Novel DMPK/ADME assay methods are readily designed and developed if a more specific or refined experimental approach is required. Methods can then be transferred elsewhere, such as to internal sites, or our bioanalytical lab can execute sample analysis. In either scenario, our team will ensure that the method is quickly activated, avoiding any delays in sample analysis. Get a quote today.

Full-service ADME and DMPK CRO

As a full-service DMPK contract research organization (CRO), our purpose-built labs and teams of consultative, accessible scientists serve as a true partner throughout the entire drug development life cycle, from drug candidate selection to monitoring bioavailability throughout clinical trials. Our ADME and DMPK expertise extends well beyond typical assay development, which usually employs enzyme-linked immunosorbent assay (ELISA) and immunoassay platforms; instead, scientific experts use a broad collection of analytical techniques. These ADME assessments can also be fully integrated with toxicity services, providing a full framework for DMPK-toxicology studies.

We are well-equipped to track drug candidates’ pharmacokinetics and metabolism for both small molecules and biologics. With all methods in hand, we can serve as your DMPK lab, testing bioavailability and drug metabolism throughout clinical research. Just send your animal or human samples to us. Get a quote for DMPK and ADME services.

DMPK analysis & ADME services

  • Novel DMPKE/ADME assay development and validation
  • DMPK-toxicology studies when integrated with toxicity services
  • DMPK & ADME method transfer and sample analysis
  • High throughput therapeutic drug monitoring (TDM)

    Therapeutic drug monitoring (TDM)

    Some drugs under investigation call for therapeutic drug monitoring (TDM) to closely track drug concentrations in patients, in addition to more routine bioavailability analysis. Drug candidates with an especially narrow therapeutic index require TDM, as therapeutic failures or harmful side effects can result from slight variations in dose or concentration. With TDM, patient samples must be routinely and rapidly tested to ensure drug levels are neither too high nor too low.

    We understand the risks associated with drugs that require TDM. For that reason, our DMPK Lab has built high-throughput capacity and accelerated workflows to keep up with demand throughout the course of clinical trials. Leaning on our promise to deliver efficient turnaround times and quality reporting, leading drug developers and biopharmaceutical organizations trust our experts to regularly measure drug concentrations in serum or plasma to ensure drug effectiveness and subject safety. Need bioanalytical support throughout your clinical trial? Talk with an expert today.

       

      Your partner for DMPK & ADME services

      Our dedicated team of industry-leading scientific experts offer a wide range of innovative ADME and DMPK solutions and services for early and late-stage discovery programs, customized to meet specific customer requirements. We are ready to partner with you, providing the highest quality ADME and DMPK services to help validate toxicology studies, support safety evaluations, and indicate the likelihood of drug-drug interactions.

      For more information about our ADME and DMPK lab testing services or to request a quote, contact us today.

       

      Unsurpassed Regulatory

      Given the sophistication of today’s pharmaceuticals and the complexity of the development process, an analytical lab partner with broad technical expertise and a strong regulatory history/performance is more important than ever. In a recent Industry Standard Research (ISR) survey, respondents noted technical expertise and regulatory history/performance as the most important criteria for selecting an analytical lab.

      Bioanalysis (Nonclinical and Clinical)

      Our laboratory uses a wide range of techniques and technology platforms to meet the needs of our customers, and more in support of PK/TK, pharmacology, bioequivalence and bioavailability studies, and biomarker assays from early discovery to post marketing. Bioanalysis is somewhat unique in that it is required for the evaluation of a therapeutic throughout the entire drug development cycle.

      Ready to Get Started?

      Give us a call and speak with an actual scientist.

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