Analysis for Polysorbate 80 Using New HPLC-CAD Method

Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) is a common nonionic surfactant, emulsifier and solubilizer that is used in a wide variety of industries and applications. A well-developed analytical method is crucial for accurately quantitating polysorbates. Due to the chemical structure and chemical properties of polysorbate 80, it cannot be accurately quantitated by analytical methods such gas chromatography or liquid chromatography with ultraviolet absorption.  This whitepaper discusses how a new analytical method using High Performance Liquid Chromatography (HPLC) with Charged Aerosol Detection (CAD) accurately quantitates polysorbate 80 in a pharmaceutical formulation.

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