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Icon Liquid Chromatography

Liquid Separations is a core service at Impact Analytical, and our knowledge and experience is key to providing you the best analysis and reliable results. With our state of the art equipment, liquid separations analysis can be performed to quantitate semi- and non-volatile compounds, or identify an unknown compound. Liquid chromatographs can be combined with a variety of analytical detectors to measure analytes in various ways to accommodate most testing needs. Impact Analytical’s advanced  equipment includes:

Liquid Chromatography-Mass Spectrometry (LC-MS) – A great way to identify unknown components. Our in-house databases have hundreds of compounds including polymer extractables, pharmaceutical impurities, surfactants, degradation products, and color bodies. We offer both electrospray (ESI) and atmospheric pressure chemical ionization (APCI) modes.

High Performance Liquid Chromatography (HPLC) – Allows quantitation of analytes with identification based on retention time of known standards. Detection systems available include Ultraviolet-visible (UV-Vis) spectroscopy, which relies on the analyte having a chromaphore, or charged aerosol detection (CAD), which can be used for those analytes that do not exhibit a chromophore. 

Ultra Performance Liquid Chromatography (UPLC) – Based on the same principles used in HPLC, the UPLC uses shorter separations columns, but allows for better peak resolution and sensitivity, shorter analysis time, and less solvent and therefore less chemical waste. Basically, it is like HPLC, but better. The UPLC can be paired with a variety of detectors, such as UV-Vis and CAD providing greater versatility.

Size Exclusion Chromatography (SEC) – A valuable tool for the characterization of molecular weight, average molecular weight and molecular weight distribution for polymers. We offer both differential refractive index (DRI) and multi-angle laser light scattering (MALLS) detection. Standard calibration is used to give relative molecular weight with DRI analysis, while MALLS detection gives “true” molecular weight.

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