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LC-MS Analysis

Liquid Chromatography - Mass Spectrometry


Liquid chromatography - mass spectrometry (LC-MS) analysis is a valuable tool for the characterization of semi- and non-volatile compounds.  Impact Analytical has a state-of-the-art liquid separations laboratory that includes an Agilent Ion Trap LC-MS system.  The ion trap system allows for MSn analysis, which is used to identify unknown components such as polymer additives, degradents, pharmaceutical impurities, and active pharmaceutical ingredients (API’s).  The system also has a UV detector, allowing for simultaneous collection of both MS and UV data to monitor for all possible components.

Examples of some of the past projects that our LC-MS testing lab has solved include:

  • LC-MS Analysis of Residues for Identification
  • LC-MS Characterization of Coatings
  • Determination of Residual Acrylamide Content by LC-MS
  • Impurity Identification by LC-MS
  • LC-MS Analysis of Leachables and Extractables
  • Method Development and Validation
  • Surfactant Analysis
  • Polymer Additive Analysis and Quantitation
  • Protein and Amino Acid Characterization by LC-MS
  • Residual Monomer and Oligomer Detection
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